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    Home » Recipes » Main Courses

    Slow Cooker Mississippi Pork Tenderloin

    Published: Apr 24, 2025 · Modified: May 10, 2025 by Karin and Ken · This post may contain affiliate links. 4 Comments

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    If you want a delicious and easy slow cooker dinner, you should try this Mississippi Pork Tenderloin. It’s juicy and moist with a flavor bomb in each bite. I love simple recipes that I can toss in the crockpot and then have ready to go at dinnertime. It’s the perfect option for big or busy families!

    Four slices of pork tenderloin over mashed potatoes and sauce.
    Jump to:
    • Why You’ll Love This Recipe
    • Ingredients
    • Variations
    • How to Make Mississippi Pork Tenderloin
    • Recipe Tips
    • Storage Directions
    • Serving Suggestions
    • Recipe FAQs
    • More Delicious Pork Dishes
    • Slow Cooker Mississippi Pork Tenderloin

    The Mississippi pork tenderloin is fall-apart tender with a bold sauce that is a dream over potatoes or rice. I like to serve it with several sides to create a different yet still tasty meal that everyone will drool over. It’s definitely my favorite variation of Mississippi pork pot roast.

    If you like easy pork tenderloin recipes, you will love this bacon wrapped Air Fryer Pork Tenderloin and my Pork Tenderloin Medallions served in a creamy mustard sauce.

    Why You’ll Love This Recipe

    • It’s a family favorite: My whole family asks for this pork recipe at least once a week. I don’t mind making it because I enjoy it just as much.
    • It’s versatile: This Mississippi tenderloin can be served with several side dishes to create an entirely new experience every time you enjoy it.
    • It’s quick to prep: I love how easy it is to prepare. In just a few minutes, all of the ingredients are ready to go in the slow cooker. There’s no hands-on cooking required!
    • It’s picky eater approved: Trying to come up with different meals is so hard when you have a picky eater. However, I have served this to family and friends who were unsure, and they all loved it. It’s worth trying!

    Ingredients

    All of the ingredients for this Mississippi pork tenderloin are listed below. They’re inexpensive and easy to find at the grocery store.

    Ingredients to cook Mississippi pork tenderloin on a table.
    • Pork tenderloin: I like to use pork tenderloin, but you may turn this into a slow-cooker Mississippi pork roast. Try this recipe with a pork shoulder instead of a tenderloin. It will take 6-8 hours on low or 3-5 hours on high, depending on the size. Even making a Mississippi pork loin is great. It has more layers of fat than a tenderloin but is a leaner cut than a roast. The cooking time will be similar to 6-8 hours on low.
    • Pork gravy mix: This adds flavor while also helping the sauce to thicken just enough to create a gravy. It’s not thick and creamy like a traditional gravy, but it coats the pork perfectly.
    • Ranch seasoning: I love the herbs and spices in ranch seasoning. I feel that they perfectly complement the pork and pepperoncini peppers. It has great garlic and dill flavor.
    • Butter: A little fat is great because tenderloin tends to be a fairly lean cut of meat. I love butter for this because it adds richness, too.
    • Pepperoncini peppers: These provide subtle heat and acidity. They are key in a Mississippi recipe!

    See the recipe card below for exact ingredient amounts, nutritional information, and detailed instructions.

    Variations

    • Garlic and herbs: Use some fresh sprigs of thyme and rosemary along with minced garlic to add depth and herb flavors.
    • French onion: Swap the ranch for French onion soup mix to give it an umami flair.
    • Beef roast: This Mississippi pot roast is made with pork; why not make it with a tender beef tenderloin for a whole new dish?

    How to Make Mississippi Pork Tenderloin

    Here are the instructions you’ll need to prepare your slow cooker Mississippi pork tenderloin. Feel free to spray the bottom of the pot to keep the pork from sticking.

    Pork tenderloin in the slow cooker.

    Step 1: Add the tenderloin. Place the pork tenderloin at the bottom of the crockpot.

    Ranch seasoning over top of the pork tenderloin.

    Step 2: Pour in water and packets. Add the water and add the gravy mix and ranch seasoning. Ensure the seasoning is covering the pork!

    Pepperoncini peppers and butter adding with the pork tenderloin.

    Step 3: Top with butter and peppers. Add pats of butter directly onto the pork tenderloin and arrange the pepperoncini peppers on and around the pork.

    Cooked tenderloin in the slow cooker.

    Step 4: Cook. Pop the lid on and cook it for 3-4 hours on low or 2-3 hours on high. It should reach a temp of 160 degrees F for ideal tenderness. Slice and enjoy!

    Recipe Tips

    • Rest the pork before serving: When you remove the pork tenderloin from the slow cooker, give it a few minutes to rest before slicing or shredding. This lets the juices redistribute, so it’s extra moist and tender.
    • Make a slurry for a thicker gravy: If you want a thick gravy, make a slurry with cornstarch and water. Add it to the slow cooker after you remove the pork and let it cook in the crockpot for a few minutes on high or until it thickens.
    • Leave the crockpot closed: Refrain from opening your crockpot as the pork cooks. This lets out all of the heat and steam, preventing it from cooking evenly.

    If you love recipes like this Mississippi pork tenderloin in a crock pot, you may also enjoy this Maple Mustard Pork Tenderloin too!

    Pouring gravy over slices Mississippi pork tenderloin.

    Storage Directions

    • Storing: Store leftovers in an airtight container for up to 4 days. Freeze the sliced pork in a freezer bag for up to 3 months.
    • Reheating: An individual portion can be reheated in the microwave. If you have more leftovers, place them in a baking dish covered with foil in a 350-degree oven for 8-10 minutes or until warm.

    Serving Suggestions

    • Potatoes are amazing with this Mississippi pork. Get creative and serve it with mashed potato fries or garlic mashed potato cakes if you aren’t feeling traditional mashed potatoes.
    • I love simple and tasty veggie side dishes like these sweet and sour green beans with this tenderloin recipe. It complements the flavors so well.
    • This French onion bread is perfect for soaking up the extra sauce and juices from the pot!
    • Finish your comforting meal with homemade raspberry cookies!
    A white plate with pork tenderloin over top of mashed potatoes and a side of peas.

    Recipe FAQs

    How do I know the tenderloin is ready?

    I like to use a thermometer to be sure! Pork must be cooked to a minimum of 145 degrees F to be safe to eat.

    Can I sear the pork first?

    Of course! Searing the meat is a great way to get even more flavor and to help seal in the juices. I skip it for convenience, and the tenderloin still comes out super delicious.

    Are pepperoncini peppers spicy?

    The spice level is very subtle. You can purchase hot pepperoni peppers if you want to bump up the heat!

    Cooked slow cooker Mississippi pork tenderloin in slices on a table.

    More Delicious Pork Dishes

    • A plate of crispy breaded cornflake pork chops garnished with lemon wedges and parsley, served on a white plate with a gold fork on the side.
      Breaded Cornflake Pork Chops
    • Pork chop casserole served up on a plate with a fork on the side.
      Easy Pork Chop Casserole
    • Pork carnitas slow cooker tacos on a cutting board on the table.
      Mexican Tacos with Pork Carnitas (Slow Cooker)
    • Slow cooker boneless pork ribs on a white plate with mashed potatoes and corn.
      Slow Cooker Boneless Pork Ribs

    If you try this recipe and love it please leave a star rating in the recipe card below or even better, drop a review in the comment section, I always appreciate your feedback. Be sure to follow along with me on Facebook, Pinterest, and YouTube for more easy recipes!

    Slices of slow cooker Mississippi pork tenderloin on a plate over mashed potatoes.

    Slow Cooker Mississippi Pork Tenderloin

    Karin and Ken
    This Mississippi Pork Tenderloin is an easy slow cooker recipe the family will love. Add the ingredients to the pot and let it cook all day to yummy perfection.
    5 from 2 votes
    Print Recipe Pin Recipe
    Prep Time 5 minutes mins
    Cook Time 4 hours hrs
    Course Main Course
    Cuisine American
    Servings 4 servings
    Calories 747 kcal

    Equipment

    • Slow Cooker

    Ingredients
      

    • 1 pound pork tenderloin You can also use 4 pork chops or a 2-5 pound pork roast.
    • 1 cup water
    • 1 packet pork gravy mix
    • 1 packet dried ranch seasoning
    • 4 tablespoons unsalted butter, thinly sliced
    • 4-8 pepperoncini peppers
    Get Recipe Ingredients

    Instructions
     

    • Place the pork tenderloin in the bottom of the slow cooker. Pour the water on top. Sprinkle the gravy mix and Ranch seasoning over the pork.
    • Place sliced butter on top of the pork. Add pepperoncini peppers on top and around the pork.
    • Put the lid on top of the slow cooker and cook for 3-4 hours on low or 2-3 hours on high.
    • The pork is done when an internal temperature reaches 160 degrees.
    • Slice the pork and serve with the cooking liquid as gravy. Enjoy every bite!

    Video

    Notes

    • Store leftover pork tenderloin in an airtight container. It will stay fresh in the fridge for up to 4 days.
    • Try searing the pork tenderloin in a super-hot skillet to get a nice brown crust on the outside. This adds flavor and locks in juices, but is not required.
    • Allow the pork tenderloin to rest for a few minutes before you slice. This ensures maximum juiciness!

    Nutrition

    Calories: 747kcalCarbohydrates: 1gProtein: 103gFat: 34gSaturated Fat: 15gPolyunsaturated Fat: 3gMonounsaturated Fat: 12gTrans Fat: 1gCholesterol: 336mgSodium: 259mgPotassium: 1823mgFiber: 0.3gSugar: 0.2gVitamin A: 391IUVitamin C: 8mgCalcium: 34mgIron: 3mg
    Keyword Mississippi pork tenderloin, slow cooker Mississippi pork
    Tried this recipe?Let us know how it was!

    This post was originally published in August 2016. It's been updated with new content and images.

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    Comments

    1. Caryn says

      May 31, 2025 at 6:36 pm

      5 stars
      This was soooo good and easy to make. I substituted jalapeno peppers (because it was what I had), and it was amazing. I will be making this again and again

      Reply
      • Karin and Ken says

        May 31, 2025 at 7:49 pm

        So happy to hear you enjoyed this recipe! It’s a personal favorite! Thanks for taking the time to let me know! You made my day! All the best. Karin

    2. Ray Lanham says

      May 02, 2024 at 4:37 am

      5 stars
      Scrumptious isn't to big a compliment. I added baby carrots sliced yellow onion, sliced celery and BBQ sauce.

      Reply
      • Karin and Ken says

        May 02, 2024 at 8:21 am

        Sounds wonderful. I’m going to try that myself! I’ve been making this recipe forever! Thank you. All the best. Karin

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    Welcome!

    We are the kitchen divas: Karin and my partner in life, Ken.

    We have been attached at the heart and hip since the first day we met, and we love to create new dishes to keep things interesting. Variety is definitely the spice of life!

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