How Long to Bake Tilapia at 375

Today, we're going to tell you how long to bake tilapia at 375 and share a delicious, easy baked tilapia recipe, as well.

I love fish, especially tilapia, but cooking it can be tricky. There's a fine line between undercooked, perfectly cooked, and overcooked. Today, I'm helping you hit the mark every time and make a delicious recipe.

Easy Baked Tilapia

This was inspired by my other tilapia recipe on this site, and pairs well with these amazing asparagus recipes.

Why You Will Love this Recipe

• It uses simple ingredients you can find at the store.
• It shows you exactly how to perfectly bake your tilapia.
• It's a delicious recipe that's so easy to make!

Top Tip:

Remove your fish as soon as it flakes with a fork for perfect tilapia filets.

Ingredients

This recipe uses just a few simple ingredients that are easily found at your local grocery store. The main players are listed here, but you'll find the complete ingredient list along with amounts in the recipe card at the end of the post.

• Fire roasted tomatoes
• Roasted red peppers
• green chilis
• Garlic
• Tilapia filets
• Italian seasoning
• Red pepper flakes
• Lemon, sliced 

Substitutions and Variations

• Fire Roasted Tomatoes - Use regular diced tomatoes, crushed tomatoes, or fresh chopped tomatoes
• Roasted Red Peppers - Diced bell peppers
• Green Chilis - Use ⅛ - ¼ teaspoon cayenne pepper or diced jalapeno peppers instead.
• Garlic - Garlic powder, garlic flakes, dehydrated garlic, shallots, chives or green onions instead.
• Olive Oil - Use avocado oil, vegetable oil, corn oil, melted butter or cooking spray instead.
• Tilapia Filets - Use salmon or a thicker fish filet or flaky, white fish such as cod, haddock, trout, snapper, flounder, catfish, sole, halibut or grouper.
• Italian Seasoning - Use basil, oregano or thyme individually or in combination instead.
• Lemon - Use orange juice or lime juice instead.
• Add Flavor - Use paprika or chili powder, a tablespoon of capers,
• Parsley for Garnish - Use chives, oregano, basil, arugula, cilantro, or more diced green chilis, roasted red peppers, and/or fire roasted tomatoes on top as garnish instead.
• Add Onion - Use some onion powder, onion flakes, dehydrated onion, green onions, leeks, scallions, diced sweet red or purple onions, or yellow or white onion to taste, if desired
• Add a Topping - Add a sprinkling of freshly grated parmesan cheese by itself, feta or goat cheese or with panko or regular breadcrumbs on top, and some fresh basil, thyme or oregano,
• Spicy - Add a teaspoon of chili pepper flakes, jalapeno powder, smoked jalapeno powder, or chipotle powder to the mixture to imbue heat into the dish. I will also occasionally add a teaspoon of our homemade hot pepper sauce, or use your favorite hot sauce, to the mixture.
• Add Vegetables - Throw in some sauteed mushrooms, or mushrooms and onions before baking or some baby spinach or baby kale before serving,
• Add More Lemon - To add extra flavor and moisture to your dish, top with some fresh squeezed lemon juice before baking, some lemon zest or serve wedges of lemon on top when serving.

Instructions

It only takes a few simple steps to make this easy recipe, and you'll be in and out of the kitchen in no time. The highlights are below, but the full instructions are available in the recipe card at the end of the post.

1: Add fire roasted tomatoes, roasted peppers, diced green chilis, and minced garlic to a greased baking dish.

2: Coat the fish in olive oil, Italian seasoning, salt, black pepper, and pepper flakes. Bake until the fish flakes easily with a fork.

Storage

Refrigerator: Store in an air-tight container for up to 3 days.

Freezer: Store in an air-tight, freezer-safe container for up to 2 months.

Reheat: Place the fish and tomato mixture in a greased baking dish and bake covered at 325 for 15 minutes until heated through.

Make Ahead: You can make this tilapia and then freeze it for future dinners.

What to Serve with Baked Tilapia

This delicious baked tilapia pairs well with a variety of side dishes. Try:

• White rice
• Brown rice
• Cilantro lime rice
• Corn casserole
• Risotto
• Mac and cheese
• Baked potatoes
• Mashed potatoes

Tips

• If adding vegetables to the baking dish, try and spread them out in an even layer so that they cook evenly.
• Choose thicker filets that may require a bit more cooking time to cook through properly and will retain their moisture as they cook.
• Always preheat your oven to 350 degrees for optimal cooking temperature.
• Don’t overcook your filets. They should be cooked through but still tender and juicy inside.
• Add fresh parsley and lemon slices on top before serving for added flavor and beautiful presentation.
• Be sure to marinate your tilapia fillets by covering with oil and seasoning both sides of the fish with salt, black pepper, Italian seasoning and red pepper flakes for maximum flavor.

FAQ

Video

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How to Bake Tilapia at 375

Ready to get cooking? Remember that you can print this recipe if you would like.