Prepare honey honey hot sauce if not using homemade. Preheat your oven to 450°F and line a large baking sheet with parchment paper for easy cleanup.
Trim the stem ends from the Brussels sprouts, remove any damaged outer leaves, and slice each sprout in half from top to bottom.
In a small bowl, whisk together the olive oil, hot honey, garlic powder, red pepper flakes, salt, and black pepper until smooth and well combined.
Pour the glaze over the Brussels sprouts in a large mixing bowl and toss until every piece is evenly coated.
Spread the Brussels sprouts onto the prepared baking sheet in a single layer with the cut sides facing down whenever possible.
Roast for 20 minutes, flipping halfway through, until the edges are crispy, caramelized, and deeply golden brown while the centers are tender.
Drizzle with additional hot honey, if desired, and garnish with freshly grated Parmesan, an extra pinch of red pepper flakes, or freshly cracked black pepper before serving.
Transfer the roasted Brussels sprouts to a serving platter. Serve immediately while they're hot and crispy.